| Attribute | Details |
|---|---|
| Name | Silagra |
| Active Ingredient | Sildenafil Citrate |
| Common Dosages | 50 mg, 100 mg |
| Manufacturer | Cipla Ltd. |
| Form | Tablet |
| Route | Oral |
| Learn More About Silagra | |
Pharmacokinetics
The absorption of Silagra 100 mg occurs rapidly. Oral intake shows significant plasma concentrations within 30 to 120 minutes. Sildenafil, the active component, is primarily metabolized in the liver. The involvement of cytochrome P450 enzymes, especially CYP3A4, plays a crucial role. This process converts sildenafil to its active metabolite. Its bioavailability approximates 40%, influenced by first-pass metabolism.
The elimination half-life spans around four hours. Sildenafil and its metabolites are excreted predominantly in feces. Renal elimination accounts for a smaller percentage. Factors like age, renal, and hepatic impairment affect pharmacokinetics. Such conditions necessitate dosage adjustments. Clinical trials have indicated consistent pharmacokinetic profiles across different demographics, provided renal and hepatic functions are normal.
Mechanism of Action
Sildenafil, the primary component of Silagra 50 mg, targets phosphodiesterase type 5 (PDE5). Inhibition of PDE5 leads to increased cyclic guanosine monophosphate (cGMP) levels. The presence of cGMP facilitates smooth muscle relaxation in the corpus cavernosum. This relaxation enhances blood flow, supporting erectile function during sexual stimulation.
The drug’s selectivity for PDE5 over other phosphodiesterase enzymes minimizes systemic side effects. Its specific action on penile tissue differentiates it from non-selective PDE inhibitors. Research indicates minimal effects on heart rate or blood pressure. However, caution is advised in patients with cardiovascular conditions. Sildenafil’s efficacy is dependent on sexual arousal, without which its effects remain dormant.
Warning & Precautions
Patients considering Silagra 100 mg must be aware of potential interactions. Nitrate medications can cause severe hypotension when combined with sildenafil. Grapefruit products may also interfere, affecting drug metabolism. Vision changes and priapism are rare but serious side effects requiring immediate medical attention.
Pre-existing conditions like cardiovascular disease, liver or kidney impairment, and retinitis pigmentosa demand caution. Regular monitoring ensures safe use. Alcohol consumption may exacerbate side effects, such as dizziness. Discussing current medications with a healthcare professional is essential before starting sildenafil. Detailed patient history aids in preventing adverse effects.
Silagra Disposal
Proper disposal of unused or expired Silagra 50 mg is crucial. Environmental contamination from pharmaceuticals is a growing concern. Patients should follow local guidelines for drug disposal. Many areas offer take-back programs to ensure safe elimination.
Household disposal methods include mixing with undesirable substances before discarding in trash. Flushing medications can lead to water contamination, hence discouraged. Pharmacists and healthcare providers can offer guidance on disposal practices. Regular checks of medicine cabinets help identify expired drugs for proper disposal.
Toxicity
Overdose of sildenafil 100 mg can result in toxicity. Symptoms include dizziness, fainting, and prolonged erection. Immediate medical intervention is necessary to prevent complications. Emergency treatments focus on symptomatic relief and supportive measures.
Animal studies have explored sildenafil’s toxicological profile. Doses exceeding therapeutic ranges demonstrate increased adverse events. Safe usage hinges on adherence to prescribed dosages. Healthcare professionals should educate patients about signs of overdose and appropriate actions. Risk of toxicity underscores the importance of responsible medication practices.
Where to Buy Silagra Online
Obtaining Silagra 50 mg online requires caution. Verification of pharmacy legitimacy is vital. Counterfeit medications pose health risks. Online platforms should adhere to regulatory standards, ensuring authenticity and patient safety.
Reputable online pharmacies offer consultation services. These services connect patients with licensed healthcare providers. Prescription verification ensures appropriate use. Consumer reviews and certifications aid in assessing online pharmacy credibility. When purchasing medications online, prioritize safety and authenticity. For more detailed information on sildenafil, refer to scientific resources such as PubMed.